Anita Hassanandani entered the film industry with nuvvu nenu in 2001, Tamil movie Samurai in 2002 although Varushamellam Vasantham released first.

She made her Hindi film debut with the 2003 thriller Kucch To Hai.

She also starred in the television show Kavyanjali

Since 2013, Anita Hassanandani became famous from the role of Shagun Arora/Bhalla on the television show Yeh Hai Mohabbatein

She was a wild card entry in season 8 of Jhalak Dikhhla Jaa

From June 2018 to May 2019, she played Vishakha a.k.a. Vish in Ekta Kapoor's Naagin 3

Anita Hassanandani married corporate professional Rohit Reddy in Goa on 14 October 2013

The couple had their first child, a boy on 9 February 2021